Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumors.
Identifieur interne : 000526 ( Main/Exploration ); précédent : 000525; suivant : 000527Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumors.
Auteurs : RBID : pubmed:23171545English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (chemistry), Antineoplastic Agents (administration & dosage), Antineoplastic Agents (chemistry), Breast Neoplasms (drug therapy), Breast Neoplasms (metabolism), Breast Neoplasms (pathology), Cell Line, Tumor, Graphite (chemistry), Humans, Mice, Mice, Inbred BALB C, Nanocapsules (diagnostic use), Nanocapsules (therapeutic use), Oxides (chemistry), Pentetic Acid (analogs & derivatives), Pentetic Acid (chemistry), Pentetic Acid (diagnostic use), Radiopharmaceuticals (chemical synthesis), Radiopharmaceuticals (diagnostic use), Receptor, erbB-2 (metabolism), Tomography, Emission-Computed, Single-Photon (methods), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Antineoplastic Agents.
- chemical , analogs & derivatives : Pentetic Acid.
- chemical , chemical synthesis : Radiopharmaceuticals.
- chemical , chemistry : Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Graphite, Oxides, Pentetic Acid.
- chemical , diagnostic use : Nanocapsules, Pentetic Acid, Radiopharmaceuticals.
- drug therapy : Breast Neoplasms.
- metabolism : Breast Neoplasms, Receptor, erbB-2.
- methods : Tomography, Emission-Computed, Single-Photon.
- pathology : Breast Neoplasms.
- chemical , therapeutic use : Nanocapsules.
- Animals, Cell Line, Tumor, Humans, Mice, Mice, Inbred BALB C, Treatment Outcome.
Abstract
Nanographene oxide (NGO) is a novel nano-wall material that tracks to tumors in vivo, and which, as a consequence of its large surface area, has the capacity to carry a large payload. This study explores the use of anti-HER2 antibody (trastuzumab)-conjugated NGO, radiolabeled with (111)In-benzyl-diethylenetriaminepentaacetic acid (BnDTPA) via ππ-stacking, for functional imaging. In two HER2-overexpressing murine models of human breast cancer, high tumor-to-muscle ratio was achieved, resulting in clear visualization of tumor using single-photon emission computed tomography (SPECT). In the BALB/neuT model and in BALB/c nu/nu mice bearing 231/H2N xenografts, tumor accumulation amounted to 12.7 ± 0.67 and 15.0 ± 3.7% of the injected dose/g (%ID/g) of tumor tissue at 72 h, with tumor-to-muscle ratios of 35:1 and 7:1, respectively. Radiolabeled NGO-trastuzumab conjugates demonstrated superior pharmacokinetics compared to radiolabeled trastuzumab without NGO, with more rapid clearance from the circulation. The use of NGO as a scaffold to build radiolabeled nano-immunoconstructs holds promise for molecular imaging of tumors.
DOI: 10.1016/j.biomaterials.2012.10.054
PubMed: 23171545
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Le document en format XML
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<author><name sortKey="Cornelissen, Bart" uniqKey="Cornelissen B">Bart Cornelissen</name>
<affiliation wicri:level="1"><nlm:affiliation>CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford OX3 7LE, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford OX3 7LE</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Able, Sarah" uniqKey="Able S">Sarah Able</name>
</author>
<author><name sortKey="Kersemans, Veerle" uniqKey="Kersemans V">Veerle Kersemans</name>
</author>
<author><name sortKey="Waghorn, Philip A" uniqKey="Waghorn P">Philip A Waghorn</name>
</author>
<author><name sortKey="Myhra, Sverre" uniqKey="Myhra S">Sverre Myhra</name>
</author>
<author><name sortKey="Jurkshat, Kerstin" uniqKey="Jurkshat K">Kerstin Jurkshat</name>
</author>
<author><name sortKey="Crossley, Alison" uniqKey="Crossley A">Alison Crossley</name>
</author>
<author><name sortKey="Vallis, Katherine A" uniqKey="Vallis K">Katherine A Vallis</name>
</author>
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<publicationStmt><date when="2013">2013</date>
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<term>Antineoplastic Agents (administration & dosage)</term>
<term>Antineoplastic Agents (chemistry)</term>
<term>Breast Neoplasms (drug therapy)</term>
<term>Breast Neoplasms (metabolism)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Cell Line, Tumor</term>
<term>Graphite (chemistry)</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Nanocapsules (diagnostic use)</term>
<term>Nanocapsules (therapeutic use)</term>
<term>Oxides (chemistry)</term>
<term>Pentetic Acid (analogs & derivatives)</term>
<term>Pentetic Acid (chemistry)</term>
<term>Pentetic Acid (diagnostic use)</term>
<term>Radiopharmaceuticals (chemical synthesis)</term>
<term>Radiopharmaceuticals (diagnostic use)</term>
<term>Receptor, erbB-2 (metabolism)</term>
<term>Tomography, Emission-Computed, Single-Photon (methods)</term>
<term>Treatment Outcome</term>
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<term>Antineoplastic Agents</term>
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<term>Antineoplastic Agents</term>
<term>Graphite</term>
<term>Oxides</term>
<term>Pentetic Acid</term>
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<term>Pentetic Acid</term>
<term>Radiopharmaceuticals</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Breast Neoplasms</term>
<term>Receptor, erbB-2</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Nanocapsules</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line, Tumor</term>
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<front><div type="abstract" xml:lang="en">Nanographene oxide (NGO) is a novel nano-wall material that tracks to tumors in vivo, and which, as a consequence of its large surface area, has the capacity to carry a large payload. This study explores the use of anti-HER2 antibody (trastuzumab)-conjugated NGO, radiolabeled with (111)In-benzyl-diethylenetriaminepentaacetic acid (BnDTPA) via ππ-stacking, for functional imaging. In two HER2-overexpressing murine models of human breast cancer, high tumor-to-muscle ratio was achieved, resulting in clear visualization of tumor using single-photon emission computed tomography (SPECT). In the BALB/neuT model and in BALB/c nu/nu mice bearing 231/H2N xenografts, tumor accumulation amounted to 12.7 ± 0.67 and 15.0 ± 3.7% of the injected dose/g (%ID/g) of tumor tissue at 72 h, with tumor-to-muscle ratios of 35:1 and 7:1, respectively. Radiolabeled NGO-trastuzumab conjugates demonstrated superior pharmacokinetics compared to radiolabeled trastuzumab without NGO, with more rapid clearance from the circulation. The use of NGO as a scaffold to build radiolabeled nano-immunoconstructs holds promise for molecular imaging of tumors.</div>
</front>
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<Month>11</Month>
<Day>30</Day>
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<Day>21</Day>
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<Issue>4</Issue>
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<Month>Jan</Month>
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<Title>Biomaterials</Title>
<ISOAbbreviation>Biomaterials</ISOAbbreviation>
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<ArticleTitle>Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumors.</ArticleTitle>
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<Abstract><AbstractText>Nanographene oxide (NGO) is a novel nano-wall material that tracks to tumors in vivo, and which, as a consequence of its large surface area, has the capacity to carry a large payload. This study explores the use of anti-HER2 antibody (trastuzumab)-conjugated NGO, radiolabeled with (111)In-benzyl-diethylenetriaminepentaacetic acid (BnDTPA) via ππ-stacking, for functional imaging. In two HER2-overexpressing murine models of human breast cancer, high tumor-to-muscle ratio was achieved, resulting in clear visualization of tumor using single-photon emission computed tomography (SPECT). In the BALB/neuT model and in BALB/c nu/nu mice bearing 231/H2N xenografts, tumor accumulation amounted to 12.7 ± 0.67 and 15.0 ± 3.7% of the injected dose/g (%ID/g) of tumor tissue at 72 h, with tumor-to-muscle ratios of 35:1 and 7:1, respectively. Radiolabeled NGO-trastuzumab conjugates demonstrated superior pharmacokinetics compared to radiolabeled trastuzumab without NGO, with more rapid clearance from the circulation. The use of NGO as a scaffold to build radiolabeled nano-immunoconstructs holds promise for molecular imaging of tumors.</AbstractText>
<CopyrightInformation>Copyright © 2012 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cornelissen</LastName>
<ForeName>Bart</ForeName>
<Initials>B</Initials>
<Affiliation>CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford OX3 7LE, UK.</Affiliation>
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<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><Agency>Cancer Research UK</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
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